Table 3.

Associations of Individual Biomarkers With Incident Heart Failure After Adjusting for Natriuretic Peptides

	Total		Men		Women
	sHR (95% CI)	p Value	sHR (95% CI)	p Value	sHR (95% CI)	p Value
Cardiac troponins	1.20 (1.14–1.26)	<0.001	1.15 (1.07–1.23)	<0.001	1.25 (1.17–1.34)	<0.001
D-dimer	1.11 (1.02–1.20)	0.01	1.08 (0.98–1.20)	0.129	1.17 (1.03–1.33)	0.014
Fibrinogen	1.07 (1.02–1.13)	0.01	1.06 (0.99–1.14)	0.112	1.10 (1.01–1.19)	0.023
C-reactive protein	1.09 (1.03–1.15)	0.001	1.07 (1.00–1.15)	0.06	1.14 (1.05–1.24)	0.001
sST2	1.04 (0.97–1.12)	0.243	1.01 (0.91–1.11)	0.857	1.07 (0.97–1.18)	0.157
Galectin-3	1.01 (0.95–1.06)	0.808	0.97 (0.90–1.04)	0.368	1.07 (0.99–1.16)	0.107
Cystatin-C	1.04 (0.99–1.09)	0.136	1.01 (0.95–1.08)	0.793	1.06 (0.99–1.14)	0.086
UACR	1.15 (1.07–1.23)	<0.001	1.10 (1.01–1.20)	0.027	1.27 (1.14–1.41)	<0.001

Fine-Gray models were adjusted for the competing risk of death, and for the following variables: age, smoking, diabetes mellitus, hypertension, body mass index, atrial fibrillation, myocardial infarction, presence of left ventricular hypertrophy/left bundle branch block, and natriuretic peptides; strata statement included. Models evaluating associations with incident heart failure in the combined (male + female) population were also adjusted for sex.

CI = confidence interval; sHR = subdistribution hazard ratio per standard deviation change in natural log-transformed biomarker; sST2 = soluble interleukin-1 receptor like 1; UACR = urinary albumin-to-creatinine ratio.