Table 4.

Sex-Specific Associations of Selected Biomarkers With Heart Failure Subtypes (HFpEF vs. HFrEF)

	Men		pequality	Women		pequality
	HFpEF	HFrEF		HFpEF	HFrEF
	sHR (95% CI)	sHR (95% CI)		sHR (95% CI)	sHR (95% CI)
Natriuretic peptides	1.32 (1.15–1.50)	1.64 (1.50–1.81)	0.012	1.30 (1.15–1.47)	1.46 (1.24–1.72)	0.289
Cardiac troponins	1.03 (0.92–1.15)	1.40 (1.30–1.50)	<0.001	1.18 (1.07–1.30)	1.36 (1.22–1.51)	0.048
C–reactive protein	1.02 (0.90–1.17)	1.16 (1.06–1.27)	0.117	1.07 (0.95–1.21)	1.33 (1.18–1.50)	0.018
UACR	1.30 (1.14–1.49)	1.21 (1.10–1.34)	0.452	1.35 (1.15–1.58)	1.16 (0.99–1.35)	0.181

Fine-Gray models adjusted for competing risk of death, other HF subtype, and unclassified HF, and for the following variables: age, smoking, diabetes mellitus, hypertension, body mass index, atrial fibrillation, myocardial infarction, and left ventricular hypertrophy/left bundle branch block; strata statement included.

HFpEF = heart failure with preserved ejection fraction; HFrEF = heart failure with reduced ejection fraction; other abbreviations as in Table 3.