Table 5.
Sex-Specific Incremental Value of Selected Biomarkers Over the Clinical Model
| Biomarkers | Men |
p Value | Women |
p Value |
|---|---|---|---|---|
| Risk Estimation | Risk Estimation | |||
| C-statistic ∗ | 0.797 (0.784–0.809) | — | 0.815 (0.804–0.827) | — |
| LHR∗ | 12376 | — | 11991 | — |
| Natriuretic peptides | ||||
| C-statistic + NPs | 0.803 (0.790–0.815) | — | 0.811 (0.799–0.823) | — |
| Δ C-statistic | 0.006 | — | −0.004 | — |
| LHR + NPs | 12,230 | — | 11,908 | — |
| LHR chi-square | 146 | <0.001 | 83 | <0.001 |
| Cardiac troponins | ||||
| C-statistic + cTns | 0.800 (0.787–0.813) | — | 0.818 (0.806–0.829) | — |
| Δ C-statistic | 0.003 | — | 0.003 | — |
| LHR + hs-Tn | 12,309 | — | 11,918 | — |
| LHR chi-square | 67 | <0.001 | 73 | <0.001 |
| C-reactive protein | ||||
| C-statistic + CRP | 0.798 (0.785–0.810) | — | 0.818 (0.806–0.829) | — |
| Δ C-statistic | 0.001 | — | 0.003 | — |
| LHR + CRP | 12,367 | — | 11,976 | — |
| LHR chi-square | 9 | 0.003 | 15 | <0.001 |
For these analyses, 8,926 men with 879 HF events and 9,328 women with 830 HF events with no missing biomarker measurements were included.
CRP = C-reactive protein; cTn = cardiac troponin; LHR = likelihood ratio test; NP = natriuretic peptide.
∗
Base model includes age, smoking, diabetes mellitus, hypertension, body mass index, atrial fibrillation, myocardial infarction, and presence of left ventricular hypertrophy/left bundle branch block; strata statement included.