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. 2020 Jul 17;83(8):725–732. doi: 10.1097/JCMA.0000000000000387

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Copyright © 2020, the Chinese Medical Association.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Fig. 8 — A, Spike protein in China sequences exhibit a conserved amino acid. We found a conserved amino acid “D” at position 614 of Spike protein in most China sequences. B, Analysis indicates three variants of spike protein in the United States. We observe three variants in the analysis of United States sequences; mutant-1 found with different amino acid “G” at position 614, mutant 2-1 with same “D” at position 614 same as China but various variants at other regions. Mutant 2-2 same as 2-1 at 614 but same as China in one region as QIS60546 indicated. (I) US case. (II) Phylogenetic analysis to map three mutants in United States and China.