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. Author manuscript; available in PMC: 2020 Sep 17.
Published in final edited form as: Anal Chem. 2019 Sep 6;91(18):11661–11669. doi: 10.1021/acs.analchem.9b02194

Scheme 1.

Scheme 1.

(a) Illustration of the subunits generated from BV (Adcetris) by IdeS and KGP enzymes. (b) Illustration of the subunits generated from T-DM1 (Kadcyla) by IdeS. (c) Cleavage sites of IdeS or KGP enzymes near the hinge region.