Table 1.
Cohort demographics and clinical characteristics on admission
|
Hydrocortisone (n = 88) |
Vitamin C + hydrocortisone (n = 52) |
|
|---|---|---|
| Age, mean (SD) | 63.6 (14.5) | 63.9 (15.7) |
| Female, n (%) | 34 (39) | 21 (40) |
| Year, n (%) | ||
| 2016 | 9 (10) | 2 (4) |
| 2017 | 69 (78) | 43 (83) |
| 2018 | 10 (11) | 7 (14) |
| APACHE IV, mean (SD) | 86.1 (28.4) | 95.1 (32.3) |
| SOFA, mean (SD) | 8.6 (3.1) | 9.9 (3.8) |
| Vasopressors, n (%) | 85 (97) | 51 (98) |
| Sepsis source, n (%) | ||
| Pulmonary | 26 (30) | 17 (33) |
| Septicemia | 15 (17) | 8 (15) |
| Gastrointestinal | 21 (24) | 10 (19) |
| Genitourinary | 13 (15) | 6 (12) |
| Skin and soft tissue infections | 1 (1) | 1 (2) |
| Other | 1 (1) | 4 (8) |
| Unknown | 11 (13) | 6 (12) |
| Admission from ED, n (%) | 29 (33) | 21 (40) |
APACHE = Acute Physiology And Chronic Health Evaluation; ED = emergency department; SOFA = sequential organ failure assessment; SD = standard deviation