Table 2.
Primary and secondary outcomes
|
Hydrocortisone (n = 88) |
Vitamin C + hydrocortisone (n = 52) |
P value | Effect size | |
|---|---|---|---|---|
| Primary outcome - hospital death, n (%) | 32 (36) | 20 (39) | 0.18 | aOR 0.52 (95% CI, 0.20 to 1.34) |
| ICU death, n (%) | 20 (23) | 16 (31) | 0.72 | aOR 0.83 (95% CI, 0.30 to 2.31) |
| Ventilator-free days, mean (SD) | 17.8 (11.8) | 16.0 (11.8) | 0.40 | − 1.8 days (95% CI, − 5.95 to 2.39) |
| Vasopressor-free days, mean (SD) | 19.7 (11.5) | 16.9 (11.8) | 0.17 | − 2.8 days (95% CI, − 6.88 to 1.25) |
| ICU length of stay, mean (SD) | 9.3 (11.7) | 11.1 (13.3) | 0.41 | 1.8 days (95% CI, − 2.57 to − 6.25) |
| Dialysis, n (%) | 39 (44) | 23 (44) | 1.00 | OR 1.00 (95% CI, 0.50 to 1.99) |
Hospital and ICU death were analyzed using a multivariable logistic regression model. All other outcomes were analyzed using t tests or Chi square tests. Adjusted effect size (adjusted odds ratio [aOR]) is provided for outcomes analyzed with logistic regression, and unadjusted effect size is provided for the remaining outcomes
CI = confidence interval; ICU = intensive care unit; SD = standard deviation