Table 3.
Comparison of predictive value of RNTIC, MELD, MELD-Na and CTP in derivation cohort and validation cohort
| Variables | AUC (95%) |
Z Statistic | P Value | Cut-off Value | Sensitivity (%) |
Specificity (%) |
PPV (%) |
NPV (%) |
Overall Accuracy (%) |
Youden Index |
|---|---|---|---|---|---|---|---|---|---|---|
| Derivation cohort | ||||||||||
| RNTIC |
0.873 (0.837–0.903) |
3.08 | 77.89 | 86.04 | 82.89 | 81.2 | 81.95 | 0.64 | ||
| MELD |
0.732 (0.687–0.774) |
8.227 | <0.001 | 24.14 | 70.35 | 70.72 | 68.29 | 72.69 | 70.54 | 0.41 |
| MELD-Na |
0.714 (0.668–0.757) |
6.868 | <0.001 | 18.00 | 84.4 | 50.50 | 60.21 | 78.17 | 66.27 | 0.35 |
| CTP |
0.703 (0.657–0.747) |
6.424 | <0.001 | 10.00 | 82.91 | 47.30 | 58.51 | 75.54 | 64.13 | 0.30 |
| Validation cohort | ||||||||||
| RNTIC |
0.845 (0.778–0.898) |
2.59 | 85.07 | 71.00 | 76.25 | 80.26 | 78.21 | 0.62 | ||
| MELD |
0.768 (0.694–0.832) |
2.867 | 0.004 | 22.24 | 69.64 | 83.00 | 68.42 | 82.83 | 77.56 | 0.53 |
| MELD-Na |
0.759 (0.684–0.824) |
2.952 | 0.003 | 19.12 | 73.21 | 71.00 | 70.83 | 70.24 | 70.51 | 0.44 |
| CTP |
0.718 (0.641–0.787) |
2.903 | 0.003 | 10.00 | 75.00 | 63.00 | 65.82 | 68.83 | 67.31 | 0.38 |
Z Statistic: compared with AUC of RNTIC, P value: compared with AUC of RNTIC, RNTIC = 0.053 × RDW + 0.027 × NLR + 0.003 × TBIL+ 0.317 × INR + 0.003 × Cr, MELD model for end-stage liver disease, CTP child-Turcotte Pugh score, MELD-Na MELD-sodium score, NLR neutrophil/lymphocyte ratio, RDW red blood cell distribution width, TBIL total bilirubin, Cr creatinine, INR international normalized ratio, HBV-ACLF hepatitis B virus related acute-on-chronic liver failure, NPV negative predictive value, PPV positive predict value