Fig. 5.

ceRNA network interaction analysis in BRCA tissue. ceRNA network interaction analysis is performed, through correlation and statistical analysis. In the example, filtering for Breast Cancer (BRCA) tissue, ceRNA network analysis evidenced an interaction between LIMA1 gene, has-miR-20b and has-miR-17 cluster and ncRNA RP11-1000B6.3. Both has-miR-20b and has-miR-17 are OncomiRs, and they act on LIMA1 tumor suppressor gene. Their interaction leads to LIMA1 mRNA degradation, thus decreasing its expression in breast cancer tissue (p-value <0.05). A ceRNA molecule (lncRNA, called RP11-1000B6.3) competing with LIMA1 for has-miR-20b and has-miR-17 cluster (p-value <0.05), is also evidenced by the web service