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. 2020 Sep 16;18:125. doi: 10.1186/s12915-020-00857-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Brain-wide baseline and sensory-evoked neuronal activity. Distribution of brain-wide calcium event rates (a) in WT, fmr1^+/−, and fmr1^−/− larvae at baseline (mean ± s.e.m.). Heat map (b) of the correlation coefficient between pairs of ROIs as a function of their Euclidean distance, with the distribution of all coefficients (right) showing no marked differences between genotypes. Z-scored activity traces (c) of all ROIs responding to stimuli for each genotype (mean ± SD). Percent of ROIs (d) in the whole brain responding to each stimulus (mean ± s.e.m). Brain-wide responses to visual flow (e), visual loom (f), and auditory (g) stimuli (all panels equivalent to five larvae), where spot color represents response strength (regression coefficient) and spot diameter depicts coefficient of determination (r² value). Ratio of ROIs (h), mean regression coefficients (i), and r² values (j) in WT versus fmr1^−/− responding to the auditory stimulus across various brain regions (mean ± s.e.m.). ON, octavolateralis nucleus; rHB, remaining hindbrain (without the cerebellum (Cb) and ON); Teg, tegmentum; TS, torus semicircularis; TeO, optic tectum; Pr, pretectum; Th, thalamus; Ha, habenulae; Tel, telencephalon. P values ≤ 0.1 are shown