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. 2020 Sep 16;18:125. doi: 10.1186/s12915-020-00857-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Regional responses to a complex auditory stimulus train. Auditory responsive ROIs (a) in WT and fmr1^−/− larvae (equivalent to five larvae). Z-scored activity trace (b) of all responsive ROIs (mean ± SD) with stimulus timing and amplitude represented (bottom). For each of six functional clusters across four brain regions (c–h), the distribution of responsive ROIs (left), percent of all ROIs belonging to the cluster, mean response strength to each of eight stimulus amplitudes (top right), and mean z-scored activity trace during the first amplitude ramp and first twelve discrete amplitudes (bottom right). Spheres (c–h, left) are color coded to genotype. Amplitudes are represented in decibels (dB) from full volume. ON, octavolateralis nucleus; Teg, tegmentum; TS, torus semicircularis; Th, thalamus. P values ≤ 0.1 are shown