Table 2.
Age < 55 years at cancer diagnosis | Age 55–69 years at cancer diagnosis | Age ≥70 years at cancer diagnosis | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Number | Prescriptions | Polypharmacy | Number | Prescriptions | Polypharmacy | Number | Prescriptions | Polypharmacy | ||||||||||
N | % | Median | IQR | % | 95% CI | N | % | Median | IQR | % | 95% CI | N | % | Median | IQR | % | 95% CI | |
Total | 42,139 | 1 | 0–2 | 9 | 8–9 | 106,606 | 2 | 0–5 | 25 | 24–26 | 113,000 | 4 | 2–7 | 46 | 46–47 | |||
Sex | ||||||||||||||||||
Male | 12,799 | 30 | 0 | 0–2 | 9 | 8–9 | 55,381 | 52 | 2 | 0–4 | 24 | 24–25 | 61,162 | 54 | 4 | 2–6 | 42 | 42–43 |
Female | 29,340 | 70 | 1 | 0–2 | 8 | 8–9 | 51,225 | 48 | 2 | 1–5 | 26 | 25–26 | 51,838 | 46 | 5 | 2–8 | 51 | 51–52 |
Cancer site | ||||||||||||||||||
Breast | 13,260 | 31 | 1 | 0–2 | 7 | 7–8 | 20,728 | 19 | 2 | 0–4 | 23 | 22–24 | 13,274 | 12 | 4 | 2–7 | 49 | 48–50 |
Lung | 3517 | 8 | 1 | 0–4 | 18 | 17–20 | 16,690 | 16 | 3 | 1–6 | 35 | 34–35 | 19,608 | 17 | 5 | 2–8 | 54 | 54–55 |
Prostate | 1392 | 3 | 1 | 0–2 | 7 | 6–9 | 19,680 | 18 | 2 | 0–4 | 20 | 20–21 | 21,238 | 19 | 3 | 1–6 | 37 | 36–38 |
Colon | 2362 | 6 | 1 | 0–2 | 9 | 8–10 | 9174 | 9 | 2 | 0–4 | 24 | 23–25 | 15,489 | 14 | 4 | 2–7 | 46 | 45–47 |
Rectum | 1675 | 4 | 0 | 0–2 | 7 | 6–9 | 6025 | 6 | 1 | 0–4 | 19 | 18–20 | 6917 | 6 | 4 | 1–6 | 40 | 39–41 |
Oesophagus | 453 | 1 | 1 | 0–3 | 13 | 10–16 | 1944 | 2 | 2 | 1–5 | 29 | 27–31 | 1866 | 2 | 4 | 2–7 | 50 | 48–52 |
Stomach | 688 | 2 | 1 | 0–2 | 10 | 8–12 | 2023 | 2 | 2 | 1–5 | 28 | 26–30 | 2467 | 2 | 4 | 2–7 | 48 | 46–50 |
Oropharynx | 237 | 1 | 1 | 0–3 | 18 | 14–24 | 568 | 1 | 2 | 0–5 | 26 | 22–30 | 168 | 0.1 | 4 | 1–7.5 | 42 | 34–49 |
Liver | 353 | 1 | 2 | 0–4 | 25 | 20–29 | 1455 | 1 | 4 | 1–7 | 42 | 39–44 | 1502 | 1 | 5 | 3–8 | 58 | 56–61 |
Pancreas | 790 | 2 | 1 | 0–3 | 14 | 11–16 | 3444 | 3 | 3 | 1–5.5 | 33 | 31–34 | 4485 | 4 | 5 | 2–8 | 51 | 50–53 |
Bladder | 461 | 1 | 1 | 0–3 | 15 | 12–19 | 2750 | 2 | 2 | 1–5 | 27 | 26–29 | 4923 | 4 | 4 | 2–7 | 47 | 45–48 |
Kidney | 1234 | 3 | 1 | 0–3 | 16 | 14–18 | 2903 | 3 | 3 | 1–6 | 36 | 34–38 | 2415 | 2 | 5 | 3–8 | 54 | 52–56 |
Uterus | 916 | 2 | 1 | 0–3 | 15 | 12–17 | 3357 | 3 | 2 | 1–4 | 24 | 22–25 | 2880 | 3 | 4 | 2–7 | 50 | 48–52 |
Cervix | 2393 | 6 | 1 | 0–2 | 5 | 4–6 | 774 | 1 | 1 | 0–4 | 21 | 18–24 | 622 | 1 | 4 | 2–7 | 43 | 39–47 |
Ovary | 1020 | 2 | 1 | 0–2 | 8 | 6–10 | 2019 | 2 | 2 | 0–4 | 20 | 19–22 | 1957 | 2 | 4 | 2–7 | 45 | 42–47 |
Malignant melanoma | 7990 | 19 | 0 | 0–1 | 4 | 4–5 | 6049 | 6 | 2 | 0–4 | 18 | 17–19 | 4968 | 4 | 4 | 2–7 | 44 | 43–45 |
Brain + CNS | 1252 | 3 | 0 | 0–2 | 6 | 5–8 | 1742 | 1 | 1 | 0–4 | 20 | 18–22 | 1367 | 1 | 4 | 1–7 | 42 | 39–44 |
Non-Hodgkin lymphoma | 555 | 1 | 1 | 0–2 | 8 | 6–11 | 1165 | 1 | 2 | 0–5 | 26 | 24–29 | 1410 | 1 | 4 | 2–7 | 46 | 43–48 |
Leukaemia | 1591 | 4 | 1 | 0–2 | 8 | 7–10 | 4116 | 4 | 2 | 0–4 | 25 | 24–26 | 5444 | 5 | 4 | 2–7 | 47 | 46–48 |
IQR interquartile range, CI confidence interval.
Polypharmacy: ≥5 prescriptions within 1 year before diagnosis and at least two prescriptions. P1: test probability Kruskal–Wallis test. P2: probability chi2 test.