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. 2020 Sep 15;10:15086. doi: 10.1038/s41598-020-72155-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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PARP1 impairs MyoD binding to p57 and myogenin regulatory regions. ChIP-qPCR analysis for PARP1 and MyoD binding to KvDMR1 and myogenin promoter (MyoG prom). Samples were prepared from CTRL, shPARP1, shPARP1-CTRL and shPARP1-PARP1 cells, collected 24 h after the shift to differentiation medium, and then immunoprecipitated with PARP1 or MyoD antibodies (αPARP1 and αMyoD, IP samples), as well as with control IgG. Protein binding is expressed as percentage of input and represents the mean ± SEM of three independent experiments. Statistical significance: p-value < 0.05 (*).