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. 2020 Apr 27;27(10):2828–2842. doi: 10.1038/s41418-020-0545-9

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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The cooperative recruitment model (ApoptoCoop) was used to classify 120 patients with stage III colorectal as apoptosis capable or resistant by C3-substrate cleavage after 300 min and was used to draw Kaplan–Meier curves (i) of disease free survival (a) and overall survival (b) and compare hazard ratios against a simplified model of apoptosis (ApoptoCell) (ii). The contribution of the molecular timer, calculated as the difference in C3-substrate cleavage with or without the molecular timer, 5 h post-MOMP in colorectal patients (c). ROC and AUC of the ability of apoptosis proteins to affect apoptosis decisions after MOMP in colorectal cancer patients (d). ROC and AUC of the ability of apoptosis proteins to affect molecular timer dependency of apoptotic resistance after MOMP in colorectal cancer patients (e). P values in C by Kruskal–Wallis with Dunn’s correction.