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. 2020 Sep 15;11(9):760. doi: 10.1038/s41419-020-02980-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Half-maximal inhibitory concentration (IC₅₀) of palbociclib for 11 human breast cancer cell lines were calculated based on the results of CCK-8 assay. b Left shows volcano plot comparing the P value versus fold change for genes from TNBC relative to non-TNBC patients. The vertical lines correspond to 2.0-fold up and down, and the horizontal line represents a P value of 0.001. Genes labeled in red represent the significantly expressed genes. Right illustrates the top 10 highly expressed genes in TNBC compared to non-TNBC patients. c Western blot analysis of lysates from 11 human breast cancer cell lines. d Up: representative immunohistochemical staining of c-myc low, medium, or high expression. Down: expression of c-myc by immunohistochemical staining in 124 breast cancer samples in tissue microarrays. e C-myc mRNA expression in luminal (n = 566), HER2 positive (n = 37), and triple-negative (n = 116) breast cancer samples from The Cancer Genome Atlas (TCGA) database. f IC₅₀ values for MCF-7 cell transfected with c-myc plasmid and MDA-MB-231 cell transfected with c-myc shRNA treated with palbociclib for 48 h. Representative images and data based on three independent experiments. Error bars indicate mean ± standard deviation.