Table 2.
Multivariate analysis of 5-year OS and RFS based on the Cox’s proportional hazards model
| Variables | 5-year OS/% | 5-year RFS/% | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Differentiation | ||||
| High | Reference | 0.221 | Reference | 0.632 |
| Medium/Low | 1.399 (0.818–2.392) | 1.155 (0.640–2.088) | ||
| T stage | ||||
| T1/T2 | Reference | 0.158 | Reference | 0.001* |
| T3/T4 | 1.399 (0.858–2.570) | 3.101 (1.656–5.808) | ||
| Nodal invasion | ||||
| Negative | Reference | 0.003* | Reference | 0.588 |
| Positive | 2.422 (1.365–4.299) | 1.178 (0.651–2.133) | ||
| TLS | ||||
| Positive | Reference | 0.005* | Reference | 0.014* |
| Negative | 3.784 (1.498–9.562) | 3.296 (1.279–8.490) | ||
| CD8 | ||||
| High | Reference | Reference | ||
| Low | 2.301 (1.237–4.281) | 0.009* | 2.467 (1.178–4.731) | 0.017* |
| CD57 | ||||
| High | Reference | Reference | ||
| Low | 1.579 (1.190–3.154) | 0.016* | 1.093 (0.553–2.158) | 0.399 |
TLS tertiary lymphoid structure; OS overall survival; RFS relapse-free survival; HR hazard ratio; 95% CI, 95% confidence interval
*P < 0.05