Table 1.
Nanoparticle characterisation and IC50 values on cancer cells of BAQ derivatives.
| Compound | Size (nm) | PDI | Zeta potential (mV) | IC50 (µM) in the 24 h treatment | |||||
|---|---|---|---|---|---|---|---|---|---|
| MIA PaCa-2 | PANC-1 | BXPC-3 | HT29 | H460 | MCF-7 | ||||
| BAQ12 | 102.5 ± 3.1 | 0.069 | 36.4 ± 1.5 | 4.1 ± 0.8 | 4.5 ± 0.9 | 2.9 ± 0.6 | 3.5 ± 1.2 | 2.7 ± 0.5 | 3.1 ± 0.1 |
| BAQ13 | 99.1 ± 2.1 | 0.097 | 39.7 ± 1.9 | 4.2 ± 1.0 | 4.3 ± 1.0 | 3.1 ± 0.2 | 3.0 ± 1.1 | 2.2 ± 0.4 | 3.7 ± 0.3 |
| BAQ14 | 137.9 ± 4.6 | 0.069 | 39.1 ± 0.4 | 16.0 ± 1.8 | 10.4 ± 1.8 | 7.5 ± 0.7 | 9.6 ± 2.0 | 24.0 ± 0.3 | 28.5 ± 3.5 |
| BAQ15 | 107.3 ± 2.6 | 0.086 | 38.0 ± 2.9 | 42.0 ± 11.7 | 34.5 ± 3.9 | 17.2 ± 2.0 | 16.1 ± 2.5 | 24.1 ± 0.4 | >60 |
| BAQ16 | 119.7 ± 2.1 | 0.082 | 40.4 ± 0.5 | 60.7 ± 13.9 | >90 | 27.6 ± 2.8 | >80 | >90 | >90 |
| BAQ18 | 96.7 ± 1.6 | 0.093 | 39.5 ± 0.8 | >90 | >90 | >90 | >100 | >90 | >90 |
| Lys05 | – | – | – | 16.7 ± 4.7 | 13.3 ± 2.0 | 7.8 ± 0.9 | 10.6 ± 3.4 | 11.1 ± 0.6 | 12.3 ± 0.7 |
| HCQ | – | – | – | 79.6 ± 8.5 | – | – | >75 | – | – |
| MSDH | – | – | – | 55.5 ± 7.1 | – | – | 30.3 ± 4.8 | – | – |
(Data are mean values ± SD, n = 3).