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. 2020 Sep 15;11:4620. doi: 10.1038/s41467-020-18474-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Phylogenetic maximum-likelihood tree of the Rep protein, scale bar refers to amino acid substitutions per site, numerical values represent bootstrap support of major nodes. The Naryaviridae, Nenyaviridae, and Vilyaviridae contain endogenous viral element sequences extracted from host genomes, respective pictograms of Entamoeba (tetranucleate cyst stage) and Giardia (flagellated trophozoite stage) are shown to indicate this. Five public viral genomes were also found to cluster within these families (MG571899.1, KU043415.1, MH617639.1, KY487991.1 and LC406405.1). b Virus GC-content positively correlates with host GC-content (linear regression, n = 79 biologically independent viral genome sequences, r² = 0.58, p = 0.01).