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. 2020 Sep 16;5:194. doi: 10.1038/s41392-020-00232-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Influence of CEPO and the EPOR blocker or the PI3K/AKT inhibitor LY294002 and CEPO on renal allograft function and survival. a Blood hemoglobin levels of rat in renal transplant alone group and renal transplant + CEPO group were tested by ELISA (five rats per group per time point). b The survival curves of allografts with different treatments (n = 20 recipients/group) was compared: renal transplant alone, renal transplant + CEPO, renal transplant + EPOR blocker + CEPO, and renal transplant + LY292004 + CEPO. c The expression levels of CREA, BUN and UPRO of recipients in different groups (five rats per group per time point) are shown. d H & E staining showing the kidney morphology of rat from different groups (21 days after surgery): sham-surgery, renal transplant alone, renal transplant + CEPO, renal transplant + EPOR blocker + CEPO, and renal transplant + LY292004 + CEPO. Scale bar, 100 µm. The representative images of each group from five samples were shown. Data are expressed as mean ± SEM (*p < 0.05, statistical significance for continues variables was estimated by Student’s t-test, survival curves were compared by Log-rank test)