Table 2.
LncRNAs interacting with histone modifiers in pancreatic cancer
| LncRNA | Molecule(s) interacting with lncRNA | Affected molecules | Epigenetic regulation caused by lncRNA on target genes | References |
|---|---|---|---|---|
| AGAP2-AS1 | EZH2 | ANKRD1 and ANGPTL4 | Silencing of ANKRD1 and ANGPTL4 | [49] |
| SNHG15 | EZH2 | P15 and KLF2 | Inhibition of P15 and KLF2 | [50] |
| TUG1 | EZH2 | RND3 and MT2A | Repressing of RND3 and MT2A | [51] |
| DUXAP10 | EZH2 and LSD1 | SMAD4 and KLF2 | Silencing of SMAD4 and KLF2 | [52] |
| IRAIN | EZH2 and LSD1 | P15 and KLF2 | Silencing of KLF2 and P15 | [53] |
| HOXA-AS1 | EZH2 and LSD1 | – | – | [54] |
| HOTAIR | EZH2 | DR5 | Decrease the expression of DR5 | [55] |
| SNHG14 | EZH2 | E-cadherin | Silencing the expression of E-cadherin | [56] |
EZH2, Enhancer of zeste homolog 2; ANKRD1, Ankyrin repeat protein 1; ANGPTL4, Angiopoietin-like 4; SNHG, Small nucleolar RNA host gene; KLF2, Kruppel-like factor 2; TUG1, Taurine upregulated 1; RND3, Rho family GTPase 3; MT2A, Metallothionein 2A; LSD1, Lysine demethylase 1; SMAD4, SMAD family member 4; IRAIN, IGF1R antisense imprinted non-protein coding RNA; HOXA-AS1, HOXA cluster antisense RNA 2; HOTAIR, HOX transcript antisense RNA; DR5, Death receptor 5