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Inhibition of HU protein DNA-binding by synthesized BDFs.
| Compounds | BDF4 | BDF5 | BDF6 |
|---|---|---|---|
| HU protein | IC50, μM (average ± SD from three runs of EMSA) | ||
| HUSpm | 5.6 ± 0.8 | 6.3 ± 0.7 | 8.2 ± 1.1 |
| HUMgal | 5.0 ± 0.6 | 5.9 ± 0.8 | 8.1 ± 1.0 |
| HUEc | 7.5 ± 1.0 | 7.5 ± 0.9 | 10 ± 1.3 |
| Activities of BDF4 against HUSpm mutants, IC50, μM (mean ± SD from three runs of EMSA) | |||
| HUSpm_R57A | HUSpm_K80A | HUSpm_R88A | HUSpm_K35T |
| 6.3 ± 1.0 | 5.9 ± 0.9 | 6.3 ± 1.2 | 1.8 ± 0.3 |
