Table 2 –
Logistic Regression predicting HFRT vs CFRT assignment:
| Univariable | Multivariable | |||||
|---|---|---|---|---|---|---|
| N = 6490 | OR | 95% CI | p-value | OR | 95% CI | p-value |
| Increasing Age | 1.02 | 1.01, 1.02 | <0.001 | 1.01 | 1.01, 1.02 | <0.001 |
| Increasing BED | 0.91 | 0.90, 0.92 | <0.001 | 0.91 | 0.90, 0.92 | <0.001 |
| Miles from hosp. | 1.00 | 1.00, 1.00 | 0.2 | 1.00 | 1.00, 1.00 | 0.3 |
| Sex (Female vs Male) | 1.07 | 0.94, 1.22 | 0.3 | 1.03 | 0.90, 1.18 | 0.7 |
| Race (White vs Other) | 0.95 | 0.79, 1.14 | 0.6 | 1.03 | 0.84, 1.26 | 0.8 |
| Insurance (Medicare vs Other) | 1.13 | 0.97, 1.32 | 0.13 | 0.99 | 0.83, 1.19 | >0.9 |
| Urban (Pop. >1 million) | 1.22 | 1.07, 1.39 | 0.003 | 1.08 | 0.94, 1.24 | 0.3 |
| Facility Type (Academic vs Other) | 1.34 | 1.16, 1.54 | <0.001 | 1.32 | 1.14, 1.54 | <0.001 |
| CDCC_TOTAL | ||||||
| 0 | Ref. | Ref. | ||||
| 1 | 1.05 | 0.90, 1.22 | 0.5 | 1.04 | 0.89, 1.21 | 0.6 |
| 2 | 1.14 | 0.92, 1.40 | 0.2 | 1.17 | 0.94, 1.45 | 0.2 |
| 3 | 1.01 | 0.72, 1.39 | >0.9 | 1.04 | 0.74, 1.45 | 0.8 |
| Year of Diagnosis >2009 | 1.15 | 1.01, 1.31 | 0.037 | 1.12 | 0.97, 1.28 | 0.12 |
| Tumor location (Upper vs Lower) | 1.02 | 0.89, 1.17 | 0.7 | 1.05 | 0.92, 1.21 | 0.5 |
| Histology | ||||||
| Squamous | Ref. | Ref. | ||||
| Adeno | 0.97 | 0.83, 1.14 | 0.7 | 1.02 | 0.86, 1.20 | 0.8 |
| Other | 1.04 | 0.89, 1.21 | 0.6 | 1.18 | 0.99, 1.40 | 0.061 |
| T-stage 3/4 | 1.43 | 1.25, 1.63 | <0.001 | 1.26 | 1.08, 1.47 | 0.004 |
| N-stage 2/3 | 0.69 | 0.60, 0.80 | <0.001 | 0.77 | 0.65, 0.91 | 0.003 |
| Location | ||||||
| East Coast | Ref. | Ref. | ||||
| Central | 0.78 | 0.68, 0.90 | <0.001 | 0.80 | 0.69, 0.93 | 0.003 |
| West Coast | 1.04 | 0.85, 1.26 | 0.7 | 1.04 | 0.84, 1.28 | 0.7 |
| Tumor laterality (Right vs Left) | 1.03 | 0.91, 1.18 | 0.6 | 1.05 | 0.92, 1.20 | 0.5 |
| Grade | ||||||
| Well/mod | Ref. | Ref. | ||||
| Poor | 0.84 | 0.70, 1.01 | 0.069 | 0.79 | 0.65, 0.96 | 0.018 |
| Not determined | 0.89 | 0.75, 1.05 | 0.2 | 0.82 | 0.69, 0.98 | 0.029 |
| Median Income <$38K | 1.03 | 0.89, 1.20 | 0.7 | 1.15 | 0.95, 1.38 | 0.14 |
| Education (No HSD vs other) | 1.05 | 0.89, 1.24 | 0.5 | 1.09 | 0.90, 1.33 | 0.4 |
Univariable (UVA) Odds Ratio (OR), 95% Confidence Interval (CI), and p-value calculated by univariable logistic regression predicting HFRT assignment. Multivariable (MVA) OR, 95% CI and p-value calculated by using multivariable logistic regression predicting HFRT assignment, adjusting for all variables in the model.
HFRT = Hypofractionated Radiotherapy, CFRT = Conventional Radiotherapy, BED = Biologic Effective Dose, HSD = High School Diploma, CDCC = Charlson Deyo Comorbidity Index