Table 3-.
Univariable and Multivariable Cox Regression Analyses Predicting OS:
| Univariable | Multivariable | |||||
|---|---|---|---|---|---|---|
| N = 6490 | HR | 95% CI | p-value | HR | 95% CI | p-value |
| HFRT vs CFRT | 1.14 | 1.06, 1.22 | <0.001 | 1.08 | 1.01, 1.16 | 0.027 |
| Increasing Age | 1.01 | 1.01, 1.01 | <0.001 | 1.01 | 1.01, 1.01 | <0.001 |
| Increasing BED | 0.98 | 0.98, 0.99 | <0.001 | 0.98 | 0.98, 0.99 | <0.001 |
| Miles from hosp. | 1.00 | 1.00, 1.00 | 0.2 | |||
| Sex (Female vs Male) | 0.83 | 0.79, 0.87 | <0.001 | 0.83 | 0.79, 0.88 | <0.001 |
| Race (White vs Other) | 1.09 | 1.02, 1.18 | 0.018 | 1.03 | 0.95, 1.11 | 0.5 |
| Insurance (Medicare vs Other) | 1.24 | 1.17, 1.32 | <0.001 | 1.14 | 1.07, 1.23 | <0.001 |
| Urban (Pop. >1 million) | 0.91 | 0.86, 0.96 | <0.001 | 0.91 | 0.86, 0.96 | <0.001 |
| Facility Type (Academic vs Other) | 0.89 | 0.84, 0.95 | <0.001 | 0.92 | 0.86, 0.97 | 0.004 |
| CDCC_TOTAL | ||||||
| 0 | Ref. | Ref. | ||||
| 1 | 1.10 | 1.03, 1.16 | 0.003 | 1.09 | 1.02, 1.15 | 0.007 |
| 2 | 1.20 | 1.10, 1.31 | <0.001 | 1.19 | 1.09, 1.30 | <0.001 |
| 3 | 1.32 | 1.16, 1.50 | <0.001 | 1.33 | 1.17, 1.51 | <0.001 |
| Year of Diagnosis >2009 | 0.91 | 0.86, 0.96 | <0.001 | 0.88 | 0.84, 0.93 | <0.001 |
| Tumor location (Upper vs Lower) | 0.84 | 0.79, 0.88 | <0.001 | 0.84 | 0.80, 0.89 | <0.001 |
| Histology | ||||||
| Squamous | Ref. | Ref. | ||||
| Adeno | 0.83 | 0.78, 0.88 | <0.001 | 0.89 | 0.84, 0.95 | <0.001 |
| Other | 0.97 | 0.91, 1.03 | 0.3 | 0.99 | 0.93, 1.06 | 0.8 |
| T-stage 3/4 | 1.17 | 1.11, 1.23 | <0.001 | 1.34 | 1.26, 1.42 | <0.001 |
| N-stage 2/3 | 1.10 | 1.03, 1.17 | 0.003 | 1.33 | 1.24, 1.43 | <0.001 |
| Location | ||||||
| East Coast | Ref. | |||||
| Central | 1.03 | 0.98, 1.09 | 0.2 | |||
| West Coast | 0.97 | 0.89, 1.05 | 0.4 | |||
| Tumor laterality (Right vs Left) | 0.98 | 0.93, 1.03 | 0.4 | |||
| Grade | ||||||
| Well/mod | Ref. | |||||
| Poor | 1.03 | 0.96, 1.11 | 0.4 | |||
| Not determined | 0.97 | 0.91, 1.04 | 0.4 | |||
| Median Income <$38K | 0.98 | 0.92, 1.04 | 0.5 | |||
| Education (No HSD vs other) | 0.94 | 0.88, 1.01 | 0.084 | |||
Univariable (UVA) Hazard Ratio (HR), 95% Confidence Interval (CI), and p-value calculated by univariable Cox proportional hazards regression with an endpoint of overall survival. Multivariate (MVA) OR, 95% CI and p-value calculated by using multivariable Cox proportional hazards regression with an endpoint of overall survival, adjusting for all variables that were significant in the UVA model. HFRT = Hypofractionated Radiotherapy, CFRT = Conventional Radiotherapy, BED = Biologic Effective Dose, HSD = High School Diploma, CDCC = Charlson Deyo Comorbidity Index