Table 2.
Between-group comparison of activated and deactivated brain regions during task 1 in patients with essential tremor (ET) and healthy controls (HC).
| ROI | Voxels | MAX Z-statistic | MAX X (mm) | MAX Y (mm) | MAX Z (mm) |
|---|---|---|---|---|---|
| ACTIVATIONS | |||||
| TASK 1—ET > HC | |||||
| FP.l | 717 | 8.26 | 66 | 84 | 39 |
| PRG.r/MFG.r | 326 | 7.75 | 19 | 66 | 48 |
| FP.r | 261 | 9 | 32 | 88 | 31 |
| Caud.r | 111 | 6.19 | 36 | 75 | 34 |
| PRG.l | 101 | 8.47 | 61 | 58 | 60 |
| TASK 1—ET < HC | |||||
| CER.r | 484 | 7.52 | 42 | 40 | 32 |
| HIPP.r | 201 | 7.17 | 31 | 59 | 26 |
| POG.l | 105 | 7.4 | 61 | 45 | 64 |
| THL.l/Caud.l | 104 | 5.45 | 51 | 56 | 45 |
| SMA | 101 | 6.16 | 48 | 51 | 61 |
| DEACTIVATIONS | |||||
| TASK 1—ET > HC | |||||
| CER.l | 8593 | − 15.4 | 48 | 19 | 18 |
| PRG.r/POG.r/LOC.r | 3776 | − 9.73 | 28 | 39 | 55 |
| PRG.l/POG.l/LOC.l/SMA | 3279 | − 10.3 | 67 | 32 | 51 |
| CER.r | 1588 | − 11.4 | 35 | 18 | 17 |
| PAC | 342 | − 6.84 | 48 | 75 | 59 |
| CGp.l | 281 | − 8.66 | 47 | 41 | 45 |
| FP.r | 252 | − 6.73 | 25 | 88 | 49 |
| AMY.r | 178 | − 7.36 | 32 | 60 | 28 |
| THL.r/Caud.r/THL.l/Caud.l | 122 | − 6.4 | 36 | 53 | 42 |
| TASK 1—ET < HC | |||||
| FP.l | 100 | − 7.9 | 61 | 83 | 52 |
Voxels, number of voxels in each significant cluster; MAX Z-statistic, value of the maximum z-statistic within the cluster; MAX X/Y/Z (mm), location of the maximum intensity voxel, given as spatial coordinate values in standard space (mm). For all clusters, the corresponding p values are FWE-corrected and < 0.05. For ease of reading, a cluster size of at least 100 voxels has been chosen for reporting the significant clusters resulting from the statistical comparisons.
AMY, amygdala; Caud, caudate; CER, cerebellum; CGp, posterior cingulate gyrus; ET, patients with essential tremor; FP, frontal pole; FWE, family-wise error; HC, healthy controls; HIPP, hippocampus; l, left; LOC, lateral occipital cortex; MFG, middle frontal gyrus; PAC, paracingulate gyrus; POG, postcentral gyrus; PRG, precentral gyrus; r, right; ROI, region of interest; SMA, supplementary motor areas; THL, thalamus.