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. 2020 Jun 30;123(6):942–954. doi: 10.1038/s41416-020-0943-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Flow cytometric analysis of podoplanin and CCR6 protein surface expression in podoplanin-positive lymphatic microvascular endothelial cells (LEC) or podoplanin-negative blood microvascular endothelial cells (BEC) (black line). Filled histogram shows isotype control. b Immunofluorescence analysis of CCR6 (red) expression of LECs and BECs [scale bars represent 50 µm]. c Immunofluorescence analysis of CD31 (green) and CCR6 (red) expression in marginal zones of a breast cancer tumour and melanoma demonstrates the co-localisation of CCR6 with microvessels in the tumour microenvironment [scale bars represent 25 µm]. CCR6 seems also expressed by cancer cells, stromal cells and immune cells infiltrating the tumour.