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. Author manuscript; available in PMC: 2020 Sep 16.
Published in final edited form as: IEEE Trans Biomed Eng. 2020 Jan 1;67(9):2490–2496. doi: 10.1109/TBME.2019.2963562

Fig. 5. Stiffness and collagen content in PDAC tumors are highly correlated both globally and regionally.

Fig. 5.

A) Visualization of stiffness, collagen and the overlay between two parameters show a good correlation in both AsPC-1 and BxPC-3 tumor lines. B) AsPC-1 tumors contain 9.6±2.7 percent collagen and average stiffness of 32±11 kPa. As for BxPC-3, collagen percentage is averaged at 13±3 percent and stiffness measured at 46±24 kPa. Both of these quantities are statistically significant between AsPC-1 and BxPC-3 tumors. C) Regional analysis to examine high stiffness and low stiffness regions demonstrates a linear correlation between Young’s modulus and collagen profile with R2 = 0.59. For each tumor, two high-stiffness and two low-stiffness regions were chosen (AsPC-l:n = 13, ROIs = 52; BxPC-3: n = 14, ROIs = 56).