Table 2.
Associations between nutritional factors and risk of grade 3+ chemotherapy toxicity
| Univariate analysis | Multivariate analysis* | |||||||
|---|---|---|---|---|---|---|---|---|
| Grade 3+ toxicity N (%) | UOR (95% CI) | p value | Grade 3+ toxicity N (%) | AOR (95% CI) | p value | |||
| No | Yes | No | Yes | |||||
| Unintended weight loss over the past 6 months | ||||||||
| ≤5.0% loss | 223 (47.3) | 249 (52.8) | 1.00 (Referent) | 209 (47.1) | 235 (52.9) | 1.00 (Referent) | ||
| 5.1-≤10.0% loss | 65 (46.4) | 75 (53.6) | 1.03 (0.71-1.51) | 0.86 | 60 (46.9) | 68 (53.1) | 0.82 (0.54-1.26) | 0.37 |
| >10.0% loss | 49 (37.1) | 83 (62.9) | 1.52 (1.02-2.26) | 0.04 | 46 (38.0) | 75 (62.0) | 0.87 (0.55-1.40) | 0.58 |
| Test for trend | 0.06 | 0.44 | ||||||
| BMI at treatment initiation (kg/m2) | ||||||||
| <18.5 | 5 (29.4) | 12 (70.6) | 1.81 (0.62-5.26) | 0.28 | 5 (29.4) | 12 (70.6) | 2.55 (0.80-8.14) | 0.11 |
| 18.5-24.9 | 125 (43.0) | 166 (57.0) | 1.00 (Referent) | 117 (44.0) | 149 (56.0) | 1.00 (Referent) | ||
| 25-29.9 | 123 (43.0) | 163 (57.0) | 1.00 (0.72-1.39) | 0.99 | 115 (42.6) | 155 (57.4) | 1.22 (0.84-1.76) | 0.30 |
| ≥30 | 86 (55.8) | 68 (44.2) | 0.60 (0.40-0.88) | 0.01 | 78 (55.7) | 62 (44.3) | 0.65 (0.42-1.01) | 0.06 |
| Test for trend | 0.009 | 0.06 | ||||||
| Albumin level at treatment initiation (mg/dL) | ||||||||
| Normal (>3.6) | 239 (50.3) | 236 (49.7) | 1.00 (Referent) | 230 (50.0) | 230 (50.0) | 1.00 (Referent) | ||
| Low (≤3.6) | 93 (37.3) | 155 (62.8) | 1.71 (1.25-2.34) | 0.0009 | 85 (36.5) | 148 (63.5) | 1.50 (1.05-2.14) | 0.03 |
Abbreviations: BMI = body mass index; UOR = unadjusted odds ratio; AOR= adjusted odds ratio; CI = confidence interval.
*
Models with adjustment for CARG Toxicity Risk Group (low, medium, high) and mutual adjustment of the three nutritional factors listed in the table.