Figure 2.

Physical activity as modified by single nucleotide polymorphism (SNP) rs2072446 predicts cognitive performance by sex. An interaction between brain-derived neurotrophic factor (BDNF)-related NGFR SNP rs2072446, physical activity, and sex indicated that there was a significant discrepancy in cognitive performance depending on rs2072446 genotype, but this effect was seen in males only. Within males engaging in light levels of physical activity, those homozygous for the dominant allele had better Modified Mini-Mental State Exam (3MS) scores compared to those with at least one minor allele. Note that differences at the sedentary level among males portrayed here were not statistically significant. Figure derived from estimated marginal means of each group while adjusting for mean baseline age and marginal means across education, apolipoprotein E (APOE) e4, subjective health, and body mass index (BMI).