Table 3.
Associations of APOE ε4 and ε2 With Survival Without Neurological Disease
| Fraction (%) of Carriers of the APOE ε4 or APOE ε2 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Participant group | Age ≤ 50 | Age = 51–60 | Age = 61–70 | Age = 71–80 | Age = 81–90 | Age > 90 | OR (95% CI) | p Value |
| Association with APOE ε4 | ||||||||
| All participants (N = 1,483) | 43/133 (32.3%) | 41/168 (24.4%) | 79/300 (26.3%) | 78/294 (26.5%) | 117/437 (26.8%) | 46/145 (31.7%) | 1.00 (0.93, 1.08) | .92 |
| Males (N = 649) | 14/44 (31.8%) | 12/65 (18.5%) | 32/124 (25.8%) | 35/134 (26.1%) | 53/214 (24.8%) | 21/64 (32.8%) | 1.02 (0.90, 1.15) | .78 |
| Females (N = 834) | 29/89 (32.6%) | 29/103 (28.2%) | 47/176 (26.7%) | 43/160 (26.9%) | 64/223 (28.7%) | 25/81 (30.9%) | 1.00 (0.91, 1.10) | .93 |
| Association with APOE ε2 | ||||||||
| All participants (N = 1,483) | 19/133 (14.3%) | 23/168 (13.7%) | 42/300 (14.0%) | 57/294 (19.4%) | 83/437 (19.0%) | 41/145 (28.5%) | 1.17 (1.07, 1.29) | .001 |
| Males (N = 649) | 5/44 (11.4%) | 8/65 (12.3%) | 19/124 (15.3%) | 29/134 (21.6%) | 36/214 (16.8%) | 18/64 (28.1%) | 1.14 (0.98, 1.32) | .087 |
| Females (N = 834) | 14/89 (15.7%) | 15/103 (14.6%) | 23/176 (13.1%) | 28/160 (17.5%) | 47/223 (21.1%) | 23/81 (28.9%) | 1.20 (1.06, 1.35) | .003 |
Notes: OR = odds ratio; CI = confidence interval. ORs, 95% CIs, and p-values result from binary logistic regression models (where the dependent variable was presence/absence of the ε4 allele, or presence/absence of the ε2 allele, and the independent variable was age at blood draw which was analyzed as a continuous variable) that were adjusted for sex in analysis of all patients, and were unadjusted in analysis of males and females. ORs are interpreted as the multiplicative increase in the odds of presence of the APOE ε4 allele (for analysis of APOE ε4) or presence of the APOE ε4 allele (for analysis of APOE ε4) corresponding to each 10-y increase in age at blood draw. The six different age categories were utilized for purposes of presentation only; age was analyzed as a continuous variable in all statistical tests of association. Information was unavailable regarding APOE genotype for six patients.