Table 3.
Estimated Frequencies of Abnormal Values According to Age
| Age, yr | HCV | Amyloid BPND | WMHV | MMSE | Memory* | DSST | HGS | Muscle mass |
|---|---|---|---|---|---|---|---|---|
| 60 | 2.1 (0.7–5.0) | 6.7 (3.1–12.5) | 3.1 (1.1–7.1) | 6.8 (3.3–12.2) | 4.4 (1.9–9.1) | 4.1 (2.0–7.6) | 1.3 (0.3–3.5) | 3.6 (1.3–8.9) |
| 65 | 4.2 (1.7–8.6) | 9.1 (5.1–14.9) | 5.4 (2.3–10.4) | 8.3 (4.5–13.7) | 7.1 (3.7–12.1) | 8.1 (4.7–12.7) | 3.4 (1.1–7.8) | 5.1 (2.1–10.5) |
| 70 | 8.6 (4.4–14.9) | 12.6 (7.9–18.4) | 8.8 (4.8–14.5) | 10.4 (6.3–15.1) | 11.2 (6.6–17.2) | 15.2 (10.4–21.6) | 8.8 (4.2–16.3) | 7.3 (3.5–12.3) |
| 75 | 16.5 (10.6–24.1) | 17.2 (12.0–23.6) | 14.6 (9.2–21.7) | 12.9 (8.9–17.7) | 17.4 (11.8–23.9) | 26.9 (20.5–34.6) | 21.9 (13.6–33.0) | 10.1 (6.1–15.5) |
| 80 | 29.6 (21.4–38.9) | 23.0 (17.4–29.3) | 23.5 (16.7–31.4) | 15.8 (11.6–20.8) | 26.1 (20.3–32.8) | 43.0 (35.0–51.2) | 44.9 (34.4–56.6) | 13.8 (9.3–19.4) |
| 85 | 47.3 (37.5–56.7) | 30.3 (23.5–37.6) | 35.5 (27.5–43.9) | 19.5 (14.5–25.4) | 37.1 (30.2–44.9) | 60.5 (50.3–69.7) | 70.5 (61.0–79.6) | 18.9 (13.7–25.1) |
| 90 | 65.6 (54.8–75.1) | 38.3 (29.5–48.0) | 49.6 (39.4–60.1) | 23.5 (17.1–31.4) | 49.9 (41.2–58.8) | 75.9 (65.7–84.0) | 87.3 (79.8–92.9) | 25.4 (18.4–34.3) |
| 95 | 79.9 (67.8–87.8) | 47.4 (35.9–59.9) | 63.7 (51.3–75.5) | 28.3 (18.9–38.3) | 62.9 (51.9–73.0) | 86.3 (78.1–92.3) | 95.1 (90.6–97.9) | 33.4 (21.3–46.5) |
| 100 | 89.3 (80.7–95.2) | 56.4 (41.7–70.2) | 75.7 (63.0–86.4) | 33.4 (20.9–47.1) | 73.6 (61.0–84.0) | 92.7 (86.6–96.7) | 98.2 (95.7–99.4) | 42.4 (26.9–59.1) |
Notes: Values are presented as % (95% confidence interval). Aging markers were defined as abnormal based on the value of the worst 5th percentile in the youngest age group (60–70 years old) (25) or an amyloid BPND equal to or above a previously defined cut point (26). The cut point value was included in the abnormal group.
BPND = nondisplaceable binding potential; CERAD = Consortium for the Establishment of a Registry for Alzheimer’s Disease; DSST = Digit Symbol Substitution Test; HGS = handgrip strength; HCV = hippocampal volume; MMSE = mini-mental state examination; WMHV = white matter hyperintensities volume.
*Assessed with CERAD memory test total score over three trials.