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. Author manuscript; available in PMC: 2021 Aug 6.
Published in final edited form as: Cell Stem Cell. 2020 Jul 15;27(2):326–335.e4. doi: 10.1016/j.stem.2020.06.018

Figure 4. Loss of DNMT3A prevents gain of differentiation-associated methylation and promotes HMR expansion.

Figure 4.

(A) Scatter plot depicting the length of control HSPCs HMRs compared to KO HMRs. (B) Scatter plot depicting the length of the same loci defined as CD34+DNMT3A-KO hypo-DMRs in the WT-LCL compared to DNMT3A-MUT LCLs. (C) Density plot depicting the distribution of regions that increase in length as calculated of the delta length of the CD34+ regions in the scatter plot in B (MUT:red and WT:gray). (D) Violin plot of methylation values at regions defined as hypermethylated in the WT-LCLs (red) compared to control CD34 (gray). (E) Methylation distribution for hyper-DMR regions between WT-LCLs and control CD34 (displayed as 500 bp upstream and downstream).