Table 3. Information of amino acids for substitution at NS5-372 and NS5-386.
| Number of hydrogen bonds formed | ||||
|---|---|---|---|---|
| Amino acid | Group | NS5-372 | NS5-386 | Substitution |
| Val (V) | Nonpolar | 2 | / | |
| Gly (G) | Nonpolar | 2 | / | To replace V or A at NS5-372 |
| Pro (P) | Nonpolar | 1 | / | To replace V or A at NS5-372 |
| Ala (A) | Nonpolar | 3 | / | |
| Ile (I) | Nonpolar | 3 | / | To replace V or A at NS5-372 |
| Leu (L) | Nonpolar | 3 | / | To replace V or A at NS5-372 |
| His (H) | Polar Basic | / | 1 | |
| Arg (R) | Polar Basic | / | 1 | To replace H or Y at NS5-386 |
| Lys (K) | Polar Basic | / | 1 | To replace H or Y at NS5-386 |
| Tyr (Y) | Polar | / | 2 | To replace H at NS5-386 |