Fig 1. Single dose PEP regimens are unable to control M. leprae growth regardless of baseline levels of bacilli.

Athymic nude mice were infected in both hind footpads with 6 x10³ M. leprae. Mice were treated with single dose rifampin (SDR), single dose ROM (rifampin, ofloxacin, minocycline), or single dose PMM (rifapentine, moxifloxacin, minocycline) at 1 day, 1 month, or 2 months post-inoculation. M. leprae were enumerated by RLEP qPCR. (A) Comparison of growth of the vehicle groups at all initial infectious doses (10², 10³, and 10⁴ bacilli). Comparison of growth at (B) 10² bacilli, (C) 10³ bacilli, and (D) 10⁴ bacilli. Bars represent the mean for each group.