Table 4. Factors associated with composite unfavourable outcome using a multivariate Cox regression (n = 858 episodes).
| Variable | Crude HR (95% CI) | P value | Adjusted HR (95% CI) | P value |
|---|---|---|---|---|
| Received Aminoglycoside | 2.47 (1.45–4.21)a | 0.001 | 3.81 (1.89–7.67) | <0.001 |
| High SPOGb score | 1.64 (0.93–2.88) | 0.09 | 1.57 (0.86–2.85) | 0.138 |
| Early-onset sepsis (within 4 hours) | 1.68 (0.98–2.87) | 0.06 | 0.98 (0.54–1.74) | 0.905 |
| Age (years) | 1.02 (0.97–1.08) | 0.47 | 0.95 (0.89–1.02) | 0.132 |
| Baseline hypotension | 4.28 (2.15–8.81) | <0.001 | 1.48 (0.38–5.72) | 0.593 |
| Unwell appearance | 4.95 (2.73–8.98) | <0.001 | 2.98 (1.02–8.66) | 0.046 |
| Received fluid bolus (≥10ml/kg) | 5.12 (2.95–8.9) | <0.001 | 3.07 (1.53–6.17) | 0.001 |
| Time to 1st antibiotic (hours) | 1.45 (1.18–1.79) | <0.001 | 1.59 (1.30–1.96) | <0.001 |
a Bold text = statistically significant, results are stratified by study site.
bAbbreviations are as follows: CI, confidence interval; HR, hazard ratio. SPOG, Swiss Paediatric Oncology Group (SPOG) rule. Unwell appearance was defined as severe sepsis or septic shock, altered conscious state, documented as ‘severely unwell’ or equivalent in the patient record or either blood pressure or respiratory rate within the mandatory emergency call range.