Table 4.

Results of the univariate and multivariable analyses for associations between clinical characteristics and probability of occult cancer

Variable	Univariate		Multivariable
	OR (95% CI)	p	OR (95% CI)	p
Institution		0.50
LAC + USC	1.00		Excluded from the model
Norris	0.85 (0.54, 1.36)
Race/ethnicity		0.58a
Hispanic	1.00		Excluded from the model
Asian	0.75 (0.36, 1.58)
Caucasian	1.15 (0.69, 1.90)
African American	0.99 (0.41, 2.42)
Others/unknown	0.34 (0.045.2.51)
Age at diagnosis (years)		0.68b
<40	1.00		Excluded from the model
40-49	1.43 (0.62, 3.29)
50-64	1.48 (0.68, 3.22)
≥65	1.23 (0.49, 3.09)
BMI		0.16b
0-18.5	Small sample size		Excluded from the model
18.6-25	1.00
26-30	1.66 (0.91, 3.05)
≥31	1.13(0.60, 2.13)
Unknown
Biomarkers		0.040a		.062a
HER2-, ER or PR+	1.00		1.00
Triple negative	0.42(0.18, 1.01)		0.38 (0.16, 0.90)
HER2+	0.71 (0.39, 1.31)		0.65 (0.35, 1.20)
HER2 missing	0.44 (0.20 0.98)		1.19(0.45, 3.16)
Mammogram density		0.670
Fatty/scattered fibroglandular	1.00		Excluded from the model
Heterogeneously dense/extremely dense	1.10(0.70, 1.74)
Unknown
Index lesion histology		0.008a
Invasive ductal/ductal carcinoma	1.00		Excluded from the model
Invasive lobular	1.13 (0.62, 2.07)
DCIS/LCIS	0.33 (0.14, 0.77)
Index lesion grade		0.27b
1	1.00		Excluded from the model
2	0.88 (0.49, 1.58)
3	0.72 (0.39, 1.32)
Unknown
Clinical stage		0.004b		.002b
0	0.24(0.056, 1.06)		0.19(0.036, 1.01)
I	1.00		1.00
II	1.88(1.07, 3.30)		2.06(1.17, 3.64)
III	1.46 (0.74, 2.89)		1.69 (0.84, 3.38)
Unknown

OR odds ratio, CI confidence interval

^aOverall p-value

^bTrend test p-value