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Schematic illustration of supramolecular fabrication on nanoparticulate agonists with hedgehog signaling activation for bone tissue regeneration, including self-assembly of PA and 20S-OHC, Alt and guanidino modification, high binding ability with Ap-PLGA scaffolds, specific binding to bone tissue, cell penetration, lysosome escape, nuclear delivery for provoking hedgehog signaling and stem cell differentiation.
