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. 2020 May 4;1(2):198–213. doi: 10.1158/2643-3230.BCD-19-0077

Figure 4.

Figure 4.

Blocking CD36 induces apoptosis in AML cells and abrogates APOC2 proleukemic effects. A, Results of the Annexin V and PI staining apoptosis assays in THP-1 cells 24 hours after treatment with either 50 μmol/L or 100 μmol/L of SSO. B, Quantification of apoptotic populations in THP-1 cells 24 hours after SSO treatment. C, The effects of CD36-blocking antibody on cell proliferation in THP-1 OE Ctrl and OE APOC2 cells. D, The effects of CD36-blocking antibody on cell proliferation in MOLM-13 OE Ctrl and OE APOC2 cells. E, The effects of CD36 blocking antibody on apoptosis 24 hours posttreatment in THP-1 OE Ctrl and OE APOC2 cells. F, The quantification of Annexin V+ cell populations in THP-1 OE Ctrl and OE APOC2 cells treated with IgG or CD36Ab. G, A comparison of BODIPY staining between THP-1 OE Ctrl and OE APOC2 cells treated with IgG or CD36Ab. H, The effects of CD36 blocking antibody on apoptosis 24 hours posttreatment in MOLM-13 OE Ctrl and OE APOC2 cells. I, The quantification of Annexin V+ cell populations in MOLM-13 OE Ctrl and OE APOC2 cells treated with IgG or CD36Ab. J, A comparison of BODIPY staining between MOLM-13 OE Ctrl and OE APOC2 cells treated with IgG or CD36Ab. The differences between the groups were analyzed using unpaired t tests (****, P < 0.0001; ***, P < 0.001; **, P < 0.01; *, P < 0.05).