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. 2020 May 4;1(2):198–213. doi: 10.1158/2643-3230.BCD-19-0077

Figure 6.

Figure 6.

Conditional knockdown of APOC2 or CD36 reduced leukemia engraftment in AML NSG murine models. A, Bioluminescent imaging of NSG mice intravenously injected with HL60 shCtrl or shAPOC2 luciferase cells. B, Representative flow cytometry showing hCD45-positive engraftment in the PB of blank, HL60 shCtrl, and HL60 shAPOC2 luciferase cells. Quantification of engraftment of HL60 cells in the PB. C, Representative flow cytometry showing hCD45-positive engraftment in the BM, PB, and spleen of MOLM-13 shCtrl, MOLM-13 shAPOC2, and MOLM-13 shCD36 luciferase cells of NSG mice. Quantification of engraftment of MOLM-13 cells in the BM, PB, and spleen. The differences between the groups were analyzed using unpaired t tests (****, P < 0.0001; ***, P < 0.001; **, P < 0.01; *, P < 0.05).