Table 3.
Variables | Uni HR | 95% CI | p-value | Multi HR | 95% CI | p-value |
---|---|---|---|---|---|---|
Age | ||||||
<60 | 1 | |||||
≥60 | 0.98 | 0.73–1.31 | 0.87 | |||
Marital | ||||||
Married | 1 | |||||
Unmarried | 1.29 | 0.57–2.93 | 0.54 | |||
BMI | ||||||
BMI<18.5 | 1 | |||||
18.5≥BMI<25 | 1.21 | 0.56–2.61 | ||||
BMI≥25 | 1.04 | 0.47–2.25 | 0.55 | |||
Sex | ||||||
Male | 1 | |||||
Female | 0.78 | 0.54–1.12 | 0.17 | |||
Smoking History | ||||||
No | 1 | |||||
Yes | 1.08 | 0.79–1.47 | 0.64 | |||
Smoking Index | ||||||
<800 | 1 | |||||
≥800 | 1.16 | 0.86–1.57 | 0.33 | |||
KPS | ||||||
≥90 | 1 | |||||
<90 | 1.03 | 0.76–1.39 | 0.85 | |||
T Stage | ||||||
T1-T2 | 1 | 1 | ||||
T3-T4 | 1.40 | 1.03–1.91 | 0.03 | 1.33 | 0.95–1.85 | 0.097 |
N Stage | ||||||
N0-N2 | 1 | 1 | ||||
N3 | 1.62 | 1.20–2.20 | 0.002 | 1.41 | 1.03–1.93 | 0.034 |
Brain Metastasis | ||||||
No | 1 | |||||
Yes | 0.98 | 0.71–1.35 | 0.90 | |||
Liver Metastasis | ||||||
No | 1 | |||||
Yes | 1.31 | 0.95–1.79 | 0.095 | |||
Bone Metastasis | ||||||
No | 1 | |||||
Yes | 1.07 | 0.78–1.47 | 0.66 | |||
Thoracic Radiotherapy | ||||||
No | 1 | 1 | ||||
Yes | 0.40 | 0.29–0.56 | <0.001 | 0.40 | 0.29–0.56 | <0.001 |
Pre-ALB | ||||||
≤40 | 1 | |||||
>40 | 0.85 | 0.61–1.18 | 0.33 | |||
Pre-ALP | ||||||
≤100 | 1 | |||||
>100 | 1.22 | 0.90–1.65 | 0.20 | |||
Pre-AAPR | ||||||
≤0.52 | 1 | |||||
>0.52 | 0.21 | 0.50–0.95 | 0.021 | |||
Post-ALB | ||||||
≤40 | 1 | |||||
>40 | 0.60 | 0.60–1.12 | 0.21 | |||
Post-ALP | ||||||
≤100 | 1 | |||||
>100 | 1.39 | 1.00–1.93 | 0.049 | |||
Post-AAPR | ||||||
≤0.52 | 1 | 1 | ||||
>0.52 | 0.61 | 0.45–0.82 | 0.001 | 0.67 | 0.49–0.92 | 0.013 |
Abbreviations: AAPR, albumin-to-alkaline phosphatase ratio; BMI, body mass index; HR, hazard ratios; KPS, Karnofsky performance score; PFS, progression-free survival.