Table 3.
Univariate and Multivariate Cox Models for PFS in Training Cohort
| Variables | Uni HR | 95% CI | p-value | Multi HR | 95% CI | p-value |
|---|---|---|---|---|---|---|
| Age | ||||||
| <60 | 1 | |||||
| ≥60 | 0.98 | 0.73–1.31 | 0.87 | |||
| Marital | ||||||
| Married | 1 | |||||
| Unmarried | 1.29 | 0.57–2.93 | 0.54 | |||
| BMI | ||||||
| BMI<18.5 | 1 | |||||
| 18.5≥BMI<25 | 1.21 | 0.56–2.61 | ||||
| BMI≥25 | 1.04 | 0.47–2.25 | 0.55 | |||
| Sex | ||||||
| Male | 1 | |||||
| Female | 0.78 | 0.54–1.12 | 0.17 | |||
| Smoking History | ||||||
| No | 1 | |||||
| Yes | 1.08 | 0.79–1.47 | 0.64 | |||
| Smoking Index | ||||||
| <800 | 1 | |||||
| ≥800 | 1.16 | 0.86–1.57 | 0.33 | |||
| KPS | ||||||
| ≥90 | 1 | |||||
| <90 | 1.03 | 0.76–1.39 | 0.85 | |||
| T Stage | ||||||
| T1-T2 | 1 | 1 | ||||
| T3-T4 | 1.40 | 1.03–1.91 | 0.03 | 1.33 | 0.95–1.85 | 0.097 |
| N Stage | ||||||
| N0-N2 | 1 | 1 | ||||
| N3 | 1.62 | 1.20–2.20 | 0.002 | 1.41 | 1.03–1.93 | 0.034 |
| Brain Metastasis | ||||||
| No | 1 | |||||
| Yes | 0.98 | 0.71–1.35 | 0.90 | |||
| Liver Metastasis | ||||||
| No | 1 | |||||
| Yes | 1.31 | 0.95–1.79 | 0.095 | |||
| Bone Metastasis | ||||||
| No | 1 | |||||
| Yes | 1.07 | 0.78–1.47 | 0.66 | |||
| Thoracic Radiotherapy | ||||||
| No | 1 | 1 | ||||
| Yes | 0.40 | 0.29–0.56 | <0.001 | 0.40 | 0.29–0.56 | <0.001 |
| Pre-ALB | ||||||
| ≤40 | 1 | |||||
| >40 | 0.85 | 0.61–1.18 | 0.33 | |||
| Pre-ALP | ||||||
| ≤100 | 1 | |||||
| >100 | 1.22 | 0.90–1.65 | 0.20 | |||
| Pre-AAPR | ||||||
| ≤0.52 | 1 | |||||
| >0.52 | 0.21 | 0.50–0.95 | 0.021 | |||
| Post-ALB | ||||||
| ≤40 | 1 | |||||
| >40 | 0.60 | 0.60–1.12 | 0.21 | |||
| Post-ALP | ||||||
| ≤100 | 1 | |||||
| >100 | 1.39 | 1.00–1.93 | 0.049 | |||
| Post-AAPR | ||||||
| ≤0.52 | 1 | 1 | ||||
| >0.52 | 0.61 | 0.45–0.82 | 0.001 | 0.67 | 0.49–0.92 | 0.013 |
Abbreviations: AAPR, albumin-to-alkaline phosphatase ratio; BMI, body mass index; HR, hazard ratios; KPS, Karnofsky performance score; PFS, progression-free survival.