Table 4.
Univariate and Multivariate Cox Models for OS in Training Cohort
| Variables | Uni HR | 95% CI | p-value | Multi HR | 95% CI | p-value |
|---|---|---|---|---|---|---|
| Age | ||||||
| <60 | 1 | |||||
| ≥60 | 1.22 | 0.88–1.68 | 0.23 | |||
| Sex | ||||||
| Male | 1 | |||||
| Female | 0.80 | 0.54–1.19 | 0.26 | |||
| Marital | ||||||
| Married | 1 | 0.91 | ||||
| Unmarried | 1.06 | 0.43–2.58 | ||||
| BMI | ||||||
| BMI<18.5 | 1 | 0.89 | ||||
| 18.5≥BMI<25 | 0.83 | 0.40–1.72 | ||||
| BMI≥25 | 0.74 | 0.35–1.55 | ||||
| Smoking History | ||||||
| No | 1 | |||||
| Yes | 1.13 | 0.80–1.59 | 0.49 | |||
| Smoking Index | ||||||
| <800 | 1 | |||||
| ≥800 | 1.17 | 0.84–1.64 | 0.35 | |||
| KPS | ||||||
| ≥90 | 1 | |||||
| <90 | 1.13 | 0.82–1.57 | 0.45 | |||
| T Stage | ||||||
| T1-T2 | 1 | 1 | ||||
| T3-T4 | 1.67 | 1.19–2.30 | 0.003 | 1.60 | 1.13–2.28 | 0.008 |
| N Stage | ||||||
| N0-N2 | 1 | |||||
| N3 | 1.36 | 0.98–1.87 | 0.068 | |||
| Brain Metastasis | ||||||
| No | 1 | |||||
| Yes | 1.18 | 0.83–1.67 | 0.37 | |||
| Liver Metastasis | ||||||
| No | 1 | |||||
| Yes | 1.51 | 1.06–2.15 | 0.022 | |||
| Bone Metastasis | ||||||
| No | 1 | |||||
| Yes | 0.81 | 0.56–1.16 | 0.25 | |||
| Thoracic Radiotherapy | ||||||
| No | 1 | 1 | ||||
| Yes | 0.46 | 0.32–0.67 | <0.001 | 0.45 | 0.32–0.66 | <0.001 |
| Pre-ALB | ||||||
| ≤40 | 1 | |||||
| >40 | 0.74 | 0.52–1.06 | 0.099 | |||
| Pre-ALP | ||||||
| ≤100 | 1 | |||||
| >100 | 1.36 | 0.98–1.89 | 0.064 | |||
| Pre-AAPR | ||||||
| ≤0.52 | 1 | |||||
| >0.52 | 0.64 | 0.46–0.91 | 0.012 | |||
| Post-ALB | ||||||
| ≤40 | 1 | |||||
| >40 | 0.78 | 0.55–1.10 | 0.153 | |||
| Post-ALP | ||||||
| ≤100 | 1 | |||||
| >100 | 1.49 | 1.04–2.12 | 0.028 | |||
| Post-AAPR | ||||||
| ≤0.52 | 1 | 1 | ||||
| >0.52 | 0.52 | 0.38–0.73 | <0.001 | 0.62 | 0.44–0.86 | 0.005 |
Abbreviations: AAPR, albumin-to-alkaline phosphatase ratio; BMI, body mass index; HR, hazard ratios; KPS, Karnofsky performance score; OS, overall survival.