Table 2.
Frequency of del(13q) by FISH analysis in molecular subtypes of MGUS and multiple myeloma
| Total | % Total | % excluding insuff PC | % ≥1 FISH abnl | Del13/13q Present | % del13 | Fisher test | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genetic classification | MGUS | MM | MGUS | MM | MGUS | MM | MGUS | MM | MGUS | MM | MGUS | MM | P |
| Insufficient PC | 107 | 190 | 28% | 10% | |||||||||
| No FISH abnormality | 72 | 118 | 19% | 6% | 26% | 7% | |||||||
| CCND: t(11;14) or t(6;14) | 64 | 341 | 17% | 18% | 23% | 20% | 32% | 21% | 13 | 125 | 20% | 37% | 0.014 |
| MMSET: t(4;14) | 8 | 155 | 2% | 8% | 3% | 9% | 4% | 10% | 6 | 127 | 75% | 82% | 0.640 |
| MAF: t(14;16) or t(14;20) | 16 | 75 | 4% | 4% | 6% | 4% | 8% | 5% | 6 | 57 | 38% | 76% | 0.005 |
| HRD11+ | 43 | 444 | 11% | 23% | 16% | 26% | 21% | 28% | 7 | 86 | 16% | 19% | 0.839 |
| HRD11− | 13 | 217 | 3% | 11% | 5% | 13% | 6% | 14% | 9 | 107 | 69% | 49% | 0.253 |
| nHRD2 | 59 | 359 | 15% | 19% | 21% | 21% | 29% | 23% | 36 | 219 | 61% | 61% | 1.000 |
| Total | 382 | 1899 | 382 | 1899 | 275 | 1709 | 203 | 1591 | 77 | 721 | 38% | 45% | 0.051 |
Note: Patients assigned to mutually exclusive groups, starting from the top, after excluding those with insufficient PCs or with no FISH abnormalities. Seventeen patients had a report of hyperdiploidy alone without mention of specific chromosomes and were excluded from the analysis. HRD11+: 11+ and at one of 3+,7+,9+,15+. nHRD2, the remaining patients (no recurrent translocation or hyperdiploidy).
Abbreviation: MM, multiple myeloma.