Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 11;14:3683–3695. doi: 10.2147/DDDT.S245445

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Zhang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

SNHG4 inhibits miR-449c-5p by targeting it. (A) The sequence of binding site to miR-449c-5p in the of SNHG4; (B) Luciferase activity assay was used to verify that SNHG4 could absorb miR-449c-5p; (C) qRT-PCR was used to detect the expression of miR-449c-5p in SNHG4 overexpression and low expression cell lines; (D-F) qRT-PCR was used to detect the expression of miR-449c-5p in blood, cerebrospinal fluid of patients and brain tissue of MCAO rats; (G) the expression of miR-449c-5p in microglia was detected by qRT-PCR after LPS treatment. ** P< 0.01 and ***P< 0.001.

Abbreviations: NC, negative control; WT, wild type; Mut, mutant; pc, pc-DNA3.1; sh, short-hairpin RNA; ACI, acute cerebral infarction; MCAO, middle cerebral artery occlusion; LPS, lipopolysaccharide.