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. 2020 Sep 11;14:3683–3695. doi: 10.2147/DDDT.S245445

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© 2020 Zhang et al.

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Effects of overexpression and inhibition of miR-449c-5p on activation and inflammatory response of microglia. (A) The overexpression and inhibition of miR-449c-5p cell models were constructed; (B) qRT-PCR was used to detect the expression of M1 markers iNOS and CD86 and M2 markers Arg1 and CD206 in microglia treated with OGD; (C) ELISA was used to detect the levels of pro-inflammatory factors (IL-1 β, IL-6, TNF- α) and anti-inflammatory factors (IL-4, IL-10, TGF- β). **P< 0.01 and ***P< 0.001 versus the control group; #P< 0.05, ##P< 0.01 and ###P< 0.001 versus the NC mimics + OGD group; ^^P< 0.01 and ^^^P< 0.001 versus the NC inhibitors +OGD group.

Abbreviations: NC, negative control; iNOS, induced nitric oxide synthase; CD, cluster of differentiation; OGD, oxygen-glucose deprivation; TNF, tumor necrosis factor; IL, interleukin; TGF, transforming growth factor.