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. 2020 Sep 11;15:6673–6688. doi: 10.2147/IJN.S257459

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© 2020 Sun et al.

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Schematic of the intracellular therapeutic mechanism of the TfR-T12-PMs.

Notes: TfR-T12-PMs were prepared for PTX delivery for glioma therapy. TfR-T12-PMs can cross over the BBB by receptor-mediated transcytosis, and specifically recognize gliomas cells.

Abbreviations: TfR-T12-PMs, TfR-T12-PEG-PLA/PTX polymeric micelles; TfR-T12, transferrin receptor-T12 peptide; PTX, paclitaxel; BBB, blood−brain barrier.