Table 3.

Effects of Bariatric Surgery on Bone Mineral Density and Marrow Adipose Tissue in the 12 Months After Sleeve Gastrectomy vs Nonsurgical Care (Controls)

Variable	Treatment	Baseline			12 months				Delta 12 months		P value within group	P value between groups 12-month change
QCT lumbar vBMD, mg/cm3	SG	200.2	±	39.4	193.3	±	37.5	−6.9	±	15.5	0.04	0.08
	controls	197.5	±	35.2	198.2	±	33.8	0.7	±	13.7	0.8
Lumbar total MAT, LWR	SG	0.37	±	0.17	0.49	±	0.25	0.11	±	0.13	0.001	0.049  a
	controls	0.39	±	0.19	0.42	±	0.16	0.03	±	0.12	0.28
Lumbar unsaturated MAT, LWR	SG	0.03	±	0.01	0.04	±	0.03	0.01	±	0.03	0.1	0.02  a
	controls	0.03	±	0.01	0.02	±	0.01	−0.007	±	0.02	0.1
Lumbar saturated MAT, LWR	SG	0.30	±	0.15	0.39	±	0.19	0.09	±	0.10	0.0007	0.07
	controls	0.32	±	0.17	0.34	±	0.15	0.03	±	0.10	0.2
Femoral diaphyseal total MAT, LWR	SG	4.89	±	2.96	3.92	±	2.33	−0.90	±	2.39	0.09	0.01
	controls	3.27	±	2.41	4.51	±	3.13	1.24	±	3.12	0.07
Femoral diaphyseal unsaturated MAT, LWR	SG	0.43	±	0.29	0.30	±	0.24	−0.12	±	0.21	0.02	0.09
	controls	0.35	±	0.42	0.38	±	0.42	0.03	±	0.35	0.7
Femoral diaphyseal saturated MAT, LWR	SG	3.35	±	1.95	2.93	±	1.73	−0.38	±	1.70	0.3	0.04
	controls	2.40	±	1.77	3.31	±	2.28	0.92	±	2.38	0.08
Tibial total MAT, LWR	SG	11.39	±	3.02	10.01	±	2.00	−1.33	±	2.47	0.04	0.002  a
	controls	9.45	±	3.37	11.32	±	2.73	2.11	±	3.46	0.01
Tibial unsaturated MAT, LWR	SG	1.31	±	0.62	1.45	±	0.76	0.19	±	0.87	0.39	0.7
	controls	1.54	±	1.03	1.86	±	0.79	0.31	±	0.92	0.14
Tibia saturated MAT, LWR	SG	8.82	±	2.41	7.72	±	1.65	−1.16	±	1.87	0.02	0.001  a
	controls	7.24	±	2.56	8.51	±	2.22	1.50	±	2.64	0.02

Abbreviations: LWR, lipid-to-water ratio; MAT, marrow adipose tissue; QCT, quantitative computed tomography; SG, sleeve gastrectomy; vBMD, volumetric bone mineral density.

^a significant after controlling for baseline weight