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. 2020 Sep 2:NEJMoa2026920. doi: 10.1056/NEJMoa2026920

Figure 5. rSARS-CoV-2 CD4+ T-cell Responses with or without Matrix-M1 Adjuvant.

Figure 5

Frequencies of antigen-specific CD4+ T cells producing T helper 1 (Th1) cytokines interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), and interleukin-2 and for T helper 2 (Th2) cytokines interleukin-5 and interleukin-13 indicated cytokines from four participants each in the placebo (group A), 25-μg unadjuvanted (group B), 5-μg adjuvanted (group C), and 25-μg adjuvanted (group D) groups at baseline (day 0) and 1 week after the second vaccination (day 28) after stimulation with the recombinant spike protein. “Any 2Th1” indicates CD4+ T cells that can produce two types of Th1 cytokines at the same time. “All 3 Th1” indicates CD4+ T cells that produce IFN-γ, TNF-α, and interleukin-2 simultaneously. “Both Th2” indicates CD4+ T cells that can produce Th2 cytokines interleukin-5 and interleukin-13 at the same time.