Figure S7.

Uncoordinated Adaptive Immunity in the Elderly, Related to Figures 6 and 7

(A-B) Correlograms of all acute COVID-19 cases age < 75 (A) and $\ge$ 75 (B). Spearman R values are shown from red (−1.0) to blue (1.0). Blank fields with dots indicate lack of signal.

(C) Correlogram of curated markers of adaptive immune responses in acute COVID-19 subjects (top) and all COVID-19 subjects (bottom). Spearman r correlation values are shown from red (−1.0) to blue (1.0). ^∗p < 0.05, ^∗∗p < 0.001, ^∗∗∗p < 0.0001. Thick black squares outlining a field indicate adjusted FDR < 0.05.

(D-E) Gating strategies for (D) naive CD8⁺ and (E) CD4⁺ T cells for acute and donors < 75 years old and $\ge$75 years old, and convalescent donors.

(F) Secreted IFNg (pg/mL) after SARS-CoV-2 CD8A/B MP stimulation, versus peak COVID-19 disease severity, acute samples (n = 21). Statistics in (F) are reported for acute samples (shown in red).

^∗p < 0.05, ^∗∗p < 0.001, ^∗∗∗p < 0.0001.