Table 1.
The Potential CircRNA Biomarkers for OSCC
| CircRNAs | Expression | Host Gene | Clinical Characteristics | Clinical Value | Models | Ref |
|---|---|---|---|---|---|---|
| circPVT1 | Up | PVT1 | Mut-p53 status | Prognostic biomarker | 115 pairs of OSCC tissues and adjacent normal tissues | 29 |
| hsa_circ_0008309 | Down | CUL3 | Pathological differentiation | Diagnostic biomarker (AUC = 0.764) | 45 pairs of OSCC tissues and adjacent normal tissues | 35 |
| hsa_circ_009755 | Down | IBTK | Pathological differentiation | Diagnostic biomarker (AUC = 0.782) | 27 pairs of OSCC tissues and adjacent normal tissues | 36 |
| circRNA_000334 | Down | SPATA6 | Pathological differentiation | Diagnostic biomarker | 42 pairs of OSCC tissues and adjacent normal tissues | 30 |
| circRNA_006740 | Down | CUL3 | Pathological differentiation | Diagnostic biomarker | 42 pairs of OSCC tissues and adjacent normal tissues | 30 |
| hsa_circ_001242 | Down | TRDMT1 | Tumor size and T stage | Diagnostic biomarker (AUC = 0.784) | 40 pairs of OSCC tissues and adjacent normal tissues | 37 |
| hsa_circ_0072387 | Down | HMGCS1 | TNM stage (P=0.050 between I and II+III) | Diagnostic biomarker (AUC = 0.746) | 63 pairs of OSCC tissues and adjacent normal tissues | 38 |
| hsa_circ_0109291 | Up | ZNF714 | TNM stage (P<0.05 between I+II and III+IV) | Prognostic biomarker | 51 pairs of OSCC tissues and adjacent normal tissues | 39 |
| hsa_circ_0086414 | Down | - | TNM stage (P=0.047 between I+II and III+IV), tumor size and lymph node metastasis | Diagnostic biomarker (AUC = 0.749) | 55 pairs of OSCC tissues and adjacent normal tissues | 40 |
| hsa_circ_0092125 | Down | - | TNM stage (P<0.001 between I+II and III+IV), tumor size and lymph node metastasis | Prognostic biomarker | 84 pairs of OSCC tissues and adjacent normal tissues | 41 |
| hsa_circ_0000140 | Down | KIAA0907 | TNM stage (P=0.031 between I+II and III+IV) and lymph node metastasis | Prognostic biomarker | 56 pairs of OSCC tissues and adjacent normal tissues | 42 |
| hsa_circ_043621 | Up | KRT14 | TNM stage (P=0.029 between I+II and III+IV), pathological differentiation and lymph node metastasis | Diagnostic biomarker | 20 pairs of OSCC tissues and adjacent normal tissues | 31 |
| hsa_circ_102459 | Down | MAST1 | TNM stage (P=0.017 between I+II and III+IV), pathological differentiation and lymph node metastasis | Diagnostic biomarker | 20 pairs of OSCC tissues and adjacent normal tissues | 31 |
| hsa_circ_0004491 | Down | ORC4 | Lymph node metastasis | Diagnostic biomarker (AUC = 0.751) | 40 pairs of OSCC tissues and adjacent normal tissues | 44 |
| hsa_circ_0001874 | Up | BICD2 | TNM stage (P=0.006 between I+II and III+IV) and tumor grade | Diagnostic biomarker (AUC = 0.863) | saliva from 3 pairs of OSCC patients and healthy controls | 33 |
| hsa_circ_0001971 | Up | FAM126A | TNM stage (P=0.019 between I+II and III+IV) | Diagnostic biomarker (AUC = 0.845) | saliva from 3 pairs of OSCC patients and healthy controls | 33 |
Note: - Means not mentioned in the paper.