Table 2.

CircRNA-miRNA-mRNA Networks and Their Functions in OSCC

CircRNAs	Expression	Host Gene	Sponge Target	Target Gene	Biological Functions in OSCC	Ref
circPVT1	Up	PVT1	miR-497-5p	Aurka/mki67/bub1	Oncogenic functions, increased cisplatin resistance	29
circPVT1	Up	PVT1	miR-125b	STAT3	Promote proliferation	45
circ-PKD2	Down	PKD2	miR-204-3p	APC2	Suppress proliferation, migration and invasion, induce apoptosis and cell cycle arrest	46
circDOCK1	Up	DOCK1	miR-196a-5p	BIRC3	Inhibit OSCC cells apoptosis	48
hsa_circ_100533	Down	-	miR‐933	GNAS	Suppress proliferation, migration and colony formation, induce apoptosis	49
circ-MMP9	Up	MMP9	miR-149	AUF1	Promote migration and invasion	52
circUHRF1	Up	UHRF1	miR-526b-5p	c-Myc/TGF-β1/ESRP1	Promote proliferation, migration, invasion and EMT	53
hsa_circ_100290	Up	SLC30A7	miR‐378a	GLUT1	Promote proliferation and glycolysis	54
hsa_circ_0000140	Down	KIAA0907	miR-31	LATS2	Suppress proliferation, migration, invasion and EMT	42
hsa_circ_0001742	Up	-	miR-634	RAB1A	Promote proliferation and invasion	43
hsa_circ_0008309	Down	CUL3	miR-136-5p/miR-382-5p	ATXN1	-	35
hsa_circ_0004491	Down	ORC4	has-miR-155-5p	SIRT1*	Suppress migration and invasion	44
hsa_circ_0072387	Down	HMGCS1	miR-29-29p/miR-141-3p	MMP2/BCL2/PTEN	Only based on bioinformatics analysis	38

Notes: - Means not mentioned in the paper, *Means only based on bioinformatics analysis without experimentally proof.