Table 5.
Parameter estimates of the population E-R analysis on exploratory PD biomarkers
| Parameter (Unit) | Estimates (RSE%) | |||||
|---|---|---|---|---|---|---|
| CD23 | MDC/CCL22 | IL22BP | LTα1/β2 | IGFBP-2 | MMP12 | |
| Emax | 0.295 (22.3) | 0.339 (18.7) | 0.391 (11.3) | 0.328 (18.8) | 0.372 (44.4) | 0.512 (10.4) |
| E50 (ng∙hr/mL) | 1340 (62.4) | 1600 (18.3) | 1420 (13.9) | 1260 (34.9) | 260 (183.8) | 1200 (11.2) |
| E0 (RFU) | 8880 (3.8) | 2420 (3.4) | 6790 (3.5) | 517 (2.9) | 891 (5.6) | 3450 (5.3) |
| γ | 5 (Fixed) | 5 (Fixed) | 4.59 (39) | 4.8 (74) | 1 (Fixed) | 5 (Fixed) |
| Between-subject variability | CV% (RSE%) | |||||
| ω2E0 | 20.6 (12.1) | 19.2 (12.0) | 19.1 (16.8) | 11.2 (25.0) | 28.5 (13.6) | 26.4 (13.3) |
| Residual variability | CV% (RSE%) | |||||
| σ2prop | 11.9 (11.1) | 14.5 (11.1) | 11.7 (10) | 16.9 (10) | 17.8 (11.6) | 16.9 (9.5) |
Abbreviations: σ2prop = variance of proportional random residual effects.